Pengaruh Pemberian Madu terhadap Penurunan Ekspresi Malondialdehid pada Telinga dalam Tikus Model Diabetes Melitus

Abstract

Background. Hearing loss is one of the many complications caused by DM. Microangiopathy and microcirculation failure due to DM causes obstacles in the delivery of nutrients and oxygen to the cochlea. DM hyperglycemia activates metabolic pathways which have an impact on the formation of free radicals, namely the formation of reactive oxygen species (ROS) due to oxidative stress. Malondialdehyde (MDA) is a secondary product and biomaker of oxidative stress. Honey is a natural product that has many impacts on health because its antioxidant properties reduce the increase in MDA levels. Objective. This study aims to evaluate the effect of giving honey on reducing MDA expression in the inner ear in a rat model of diabetes mellitus induced by alloxan. Results. Giving honey had an impact on reducing the average MDA expression in the inner ear of DM model mice, both in the preventive and curative groups. Administration of high doses of honey showed a decrease in MDA expression in the inner ears of mice in both the preventive and curative groups. The Kruskal Wallis test results obtained a p value <0.05. Conclusion. Honey can reduce the expression of malondialdehyde (MDA) in the cochlea of experimental animals induced by DM.