| dc.description.abstract | Background. Type 2 diabetes mellitus (T2DM) characterized by elevated levels
of blood glucose. DM treatment using conventional medicine often causes side
effects, so people are starting to switch to herbal medicine, such as Anredera
cordifolia leaves or known as binahong. Binahong leaves contain various
metabolites such as flavonoid which are known to have antidiabetic effects.
Objective. To determine the effect of administering ethanol extract of Anredera
cordifolia (Ten.) Steenis leaves on reducing blood sugar levels in T2DM rats.
Methods. This study is a true experimental in vivo with pre-post test control
group design. This study used 30 rats consisting of 6 groups: normal control,
negative control, positive control (metformin), ethanol extract of binahong leaves
dose 25 mg/kgBW, ethanol extract of binahong leaves dose 50 mg/kgBW and
ethanol extract of binahong leaves dose 100 mg/kgBW. The treatment group was
induced by HFD for 14 days and injected with streptozotocin 30 mg/kgBW
followed by ethanol extract of binahong leaves for 14 days. Rat blood sugar levels
were evaluated 7 and 14 days after administration of binahong leaf ethanol
extract. Data analysis used parametric and Wilcoxon non-parametric statistical
test. Results. Ethanol extract of binahong leaves dose 25 mg/kgBB, 50 mg/kgBB
and 100 mg/kgBB had an effect on reduced blood glucose significantly.
Conclusion. Ethanol extract of binahong leaves can reduce the blood glucose in
rats significantly. | en_US |
