Efektivitas Ekstrak Buah Mengkudu (Morinda Citrifolia) dalam Menghambat Pertumbuhan Bakteri Streptococcus Viridans Penyebab Dry Soket Pasca Ekstraksi Secara In Vitro

Abstract

Tooth extraction is a surgical procedure that involves bone tissue and soft tissue from the oral cavity. Post-extraction wound healing generally proceeds normally, but sometimes there are problems and complications in the form of dry socket. Streptococcus viridans bacterial infection is one of the causes of dry socket, therefore preventing infection can be done by providing antibiotic or antibacterial (antiseptic) therapy. Noni (Morinda citrifolia) is a herbal plant that has an antibacterial effect against the bacteria Streptococcus viridans. The aim of this research is to determine the effectiveness of noni extract (Morinda citrifolia) against Streptococcus viridans bacteria in sockets post-extraction. The type of research is laboratory experimental with a Post test only control group design, the research samples used are colonies of Streptococcus viridans bacteria; Dilution of noni fruit extract (Morinda citrifolia) using 5 concentrations (3.125%, 6.25%, 12.5%, 25%, and 50%); Positive control Chlorhexidine diglocunate 0.2%; And DMSO as a negative control. The research data were tested using Kruskal-Wallis followed by the Post Hoc (Mann-Whitney) test and Pearson-correlation test. The results showed an average concentration value of 3.125% (6.95 mm), concentration 6.25% (7.50 mm), concentration 12.5% (8.25 mm), concentration 25% (8.95 mm) , 50% concentration (12.80 mm), negative control (0 mm), and positive control (16.95 mm). It was concluded that noni fruit extract (Morinda citrifolia) was effective in inhibiting the growth of Streptococcus viridans bacteria with an effective dose of 50%, however the antibacterial activity was still below that of Chlorhexidine glocunate 0.2%.