Korelasi Mean Platelet Volume (MPV) dan Immature Platelet Fraction (IPF) dengan Nilai Troponin I pada Pasien Sindrom Koroner Akut

Abstract

BACKGROUND. Acute coronary syndrome is a leading cause of death worldwide, with platelet activation playing a crucial role in the formation and evolution of atherothrombosis. Platelet indices, such as Mean Platelet Volume (MPV) and Immature Platelet Fraction (IPF), play a significant role as indicators of platelet activation. Troponin I is a specific protein for myocardium and serves as an ideal biomarker, providing crucial insights into the extent of myocardial damage. METHOD. This research is a cross-sectional study involving 52 acute coronary syndrome patients undergoing treatment at H. Adam Malik Hospital, Medan, from February 2023 to May 2023. Blood samples were taken upon admission, and examinations for MPV, IPF, and Troponin I were conducted. The data were analyzed using SPSS software, and the Spearman test was employed. A p-value less than 0.05 was considered statistically significant. RESULTS. Insignificant results and a very weak correlation were obtained, between MPV and Troponin I with a p-value of 0.251 and a r-value of 0.162. Similarly, there were insignificant results and a very weak correlation between IPF and Troponin I, with a p-value of 0.090 and a r-value of 0.237. However, a strong correlation was observed between MPV and IPF (r = 0.840) with a p-value of less than 0.001. CONCLUSION. The findings indicate insignificant results and a very weak correlation between MPV and IPF values in relation to Troponin I levels in acute coronary syndrome patients.