| dc.description.abstract | BACKGROUND. Acute coronary syndrome is a leading cause of death
worldwide, with platelet activation playing a crucial role in the formation and
evolution of atherothrombosis. Platelet indices, such as Mean Platelet Volume
(MPV) and Immature Platelet Fraction (IPF), play a significant role as indicators
of platelet activation. Troponin I is a specific protein for myocardium and serves
as an ideal biomarker, providing crucial insights into the extent of myocardial
damage.
METHOD. This research is a cross-sectional study involving 52 acute coronary
syndrome patients undergoing treatment at H. Adam Malik Hospital, Medan, from
February 2023 to May 2023. Blood samples were taken upon admission, and
examinations for MPV, IPF, and Troponin I were conducted. The data were
analyzed using SPSS software, and the Spearman test was employed. A p-value
less than 0.05 was considered statistically significant.
RESULTS. Insignificant results and a very weak correlation were obtained,
between MPV and Troponin I with a p-value of 0.251 and a r-value of 0.162.
Similarly, there were insignificant results and a very weak correlation between
IPF and Troponin I, with a p-value of 0.090 and a r-value of 0.237. However, a
strong correlation was observed between MPV and IPF (r = 0.840) with a p-value
of less than 0.001.
CONCLUSION. The findings indicate insignificant results and a very weak
correlation between MPV and IPF values in relation to Troponin I levels in acute
coronary syndrome patients. | en_US |
