Efektivitas Penggunaan Gel Kitosan Kepiting Hitam (Scylla Serrata) Terhadap Penyembuhan Luka Insisi pada Mukosa Rongga Mulut Tikus Galur Wistar (Rattus Norvegicus)

Abstract

A wound is a break in continuity of tissue that occur due to trauma or surgery. In the field of oral surgery, incisional wound are one of the wounds that most often occur after surgery. Incision wound can heal well but not infrequently can cause complications so wound healing agents can be used in an effort to help the wound healing. Giant mud crab shell is a natural material which can be processed into chitosan which has potential to help the healing of incision wound in the oral cavity mucosa. This study aims to determine the effectiveness of giant mud crab chitosan gel for incision wound healing in the oral mucosa of Wistar rats. This type of research is true experimental with the samples were male Wistar rats which were divided into five groups, namely gengigel group as a positive control, chitosan gel 1%, 3%, 5%, and CMC-Na as a negative control group. This research was carried out by observing erythema and length of wound closure on days 1, 3 and 7. Pearson chi-square test and Kruskall Wallis test showed that the use of 1%, 3% and 5% chitosan gel was effective in healing oral mucosal incision wound in Wistar rats, with a concentration of 3% chitosan gel is the most effective gel concentration