Pemanfaatan Gel Ekstrak Daun Petai Cina (Leucaena Glauca, Benth) Konsentrasi 6% dan 15% Terhadap Jumlah Makrofag pada Penyembuhan Gingivitis Tikus Wistar Jantan

Abstract

Chinese petai is one of the plants that grows abundantly in Indonesian. The ingredients contained in Chinese petai leaves (Leucaena glauca, Benth) have anti-inflammatory and antibacterial properties which have the potential to cure gingivitis. Gingivitis is a type of periodontal disease that often occurs due to bacterial infection of plaque. Porphyromonas gingivalis is the dominant bacteria that releases endotoxins, causing symptoms such as redness, swelling and pain of the gingiva. A phagocytic cells that is known as the first line of the defense in killing pathogens are macrophages. Scaling is the basic treatment of gingivitis, but drug therapy is still needed to speed up the healing process. The aim of this research was to produce a preparation in the form of petai cina leaf extract gel with concentrations of 6% and 15% in the oral mucosa and to determine the effect of administering petai cina leaf extract gel on the number of macrophage cells in the gingiva of male Wistar rats induced by Porphyromonas gingivalis bacteria and the occurrence of gingivitis. This research was a true experiment with a posttest-only control group design with 40 male Wistar rats that inclusively and exclusively bull field. The samples that are used in the research were gingival tissue in the mandibular incisors of male Wistar rats (Rattus novergicus). The results of the gel evaluation showed that the gel was good and there was a significant effect on the in vivo test. The results of the LSD post hoc test showed significant differences (p≤0.05) between treatment groups. The conclusion is that 6% and 15% petai cina (Leucaena glauca, Benth) leaf extract gel showed an influence on the number of macrophage cells in the gingiva of male Wistar rats with gingivitis