Sintesis dan Karakterisasi Karboksimetil Kitosan dengan Nanogold dalam Sediaan Moisture Gel sebagai Whitening Agent

Abstract

The development of cosmetics from time to time has made significant advances, especially in the preparation of moisture in gel form. Moisture gel is a semisolid system consisting of a suspension made up of small organic particles or large organic molecules, penetrated by a liquid, gel or also known as jelly. jelly. Gel has the ability to moisturize with ingredients that contain lots of water, has a cooling effect which is good for use in hot weather and is suitable for oily skin, so it is very suitable for use on Indonesian skin. Carboxymethyl chitosan has more carboxyl groups so that hydrogen bonds occur with water molecules, so it can hind water more strongly which has the potential to keep facial skin moisturised. Nano gold in the preparation has a function as an antidote to free radicals and anti-bacterial. In the study, Niacinamide was used as a whitening agent or anti-stain in the preparation of moisture gel. The purpose of this study was to formulate and evaluate a moisture gel preparation using nanogold and carboxymethyl chitosan containing niacinamide as a whitening agent or anti-stain. Moisture gel formadation was carried out by preparing a concentration of 20 ppm nanogold, 0.20% carboxymethyl chitosan and 3% concentration of niacinamide which were then mixed with a gel base with a concentration of 0.30% Evaluation of moisture gel preparations containing nanogold, carboxymethyl chitosan and niacinamide includes stability test pH test, homogeneity text, viscosity test, irritation test, anti-stain effectiveness test (moisture, smoothness, pores, stains and wrinkles), antioxidant test and antibacterial test. The results of the evaluation of the moisture gel were stable in storage for 4 weeks at room temperature. pH 5.6-4.5: homogeneous, viscosity 64.5 mPs; does not irritate the skin. The effectiveness of anti-staining moisturizing gel preparations gives percent moisture recovery 13.33%-83.33%, smoothness 17.64%-50%, pore 54.54%-86.36%, stain 76.92%-96.29%, and wrinkles 61.11% -88.88%, the zone of inhibition for S. aureus and P. acnes bacteria with optimum values were 8.5 mm and 12.5 mm respectively and the percentage of antioxidant activity was 53.49% Thus it

can be concluded that nanogold and carboxymethyl chitosan containing niacinamide

as whitening agents can be formulated into cosmetic moisture gel preparations.