Penyediaan Komposit Pembalut Luka Diabetes Berbasis Selulosa Bakteri dengan Impregnasi Mikroenkapsulasi Andaliman (Zanthoxylum acanthopdium) dan Potensinya sebagai Pembalut Luka Diabetes

Abstract

Diabetic foot ulcers or better known as Diabetic Foot Ulcer (DFU) is a common complication of diabetes mellitus that can lead to infection, amputation and even death. Wound healing processes such as DFU can be done with the use of wound dressings. Bacterial cellulose is a good material used as a wound dressing. But the weakness of this bacterial cellulose does not have antibacterial properties. Andaliman ( Zanthoxylum acanthopdium ) known to have antioxidant, antibacterial and anti-inflammatory abilities that can support SB as a wound dressing. Chitosan is known as a material that has antibacterial properties and binds red blood cells, while gelatin is known as a material that has hemostatic properties. Microencapsulation is the process of coating the core material using a coating material that aims to protect bioactive compounds from environmental influences. This research is focused on the manufacture of andaliman microencapsulated wound dressing composite and its potential as a diabetic foot ulcer dressing with variations in microencapsulated gelatin. The results of the FTIR and SEM analysis showed that the andaliman impregnation process was successful. Other aspects such as moisture content and porosity also indicate that the andaliman microencapsulated SB has the potential to be used as a wound dressing. FTIR analysis can be seen by the formation of wave numbers at 1550 cm -1 bending NH amide band which indicates the formation of microencapsulation. Characterization using SEM showed that the andaliman microencapsulation penetrated the SB fiber well. In XRD analysis, it was found that the addition of andaliman microencapsulation on SB fibers can reduce the crystallinity index of the wound dressing composite , namely SB = 54.4%, SB1:0 = 52.06%, SB1:1 = 52.17%, SB1 :2 = 52.47%, SB1:3 = 51.28%, SB1:4 = 44.46% . Meanwhile, the antibacterial test of the wound dressing showed a good antibacterial effect on E.coli and S.aureus bacteria with inhibition zones of 8.8 mm, respectively; 9.3 mm; 6 mm; 7.2 mm and 6 mm.