| dc.description.abstract | Burns need to be treated with a wound dressing, because the condition of an open wound can be contaminated with bacteria so that it prolongs the healing process. The use of gauze as a wound dressing is not effective because it does not optimally absorb wound exudate and there are no active substances that help the wound healing process. The provision of SB-based wound dressings with the addition of the active ingredient nanoencapsulated andaliman with the ex-situ can increase the ability of SB as an antibacterial and anti-inflammatory so that it is suitable to be applied as a burn dressing. The SB impregnation process was carried out with various volumes of andaliman nanoencapsulation 0mL, 70mL, 90mL, 110mL, and 130mL to see the effect of volume on the impregnation process. The results of FTIR and SEM analysis showed that the nanoencapsulation impregnation process went well. With FTIR analysis, the absorption value is obtained at a wave of 1576 cm-1 which shows the bending of the NH amide band. This band was found in SB/N with high peak intensity, proving the interaction between SB and nanoencapsulation. The appearance of the SEM test image shows that the nanoencapsulation is trapped into the bacterial cellulose fiber optimally at a variation of 130mL. XRD analysis showed that the andaliman nanoencapsulation was trapped in the SB fiber which was supported by a decrease in the crystallinity of the SB compared to the impregnated SB. The supporting characteristics of SB/N can be used as wound dressing materials, namely by testing the porosity and water content to produce good values. Antibacterial testing against Escherichia coli and Staphylococcus aureus showed good results against SB/N 110 and SB/N 130. In-vivo test for second-degree burns on 28 Rattus norvegicus showed a variation of SB/N 130 to get a good percent wound closure. greater than the gauze on the 15th day. | en_US |
