Uji Efektivitas Emulgel Minyak Ikan Kembung (Rastrelliger sp) terhadap Jumlah Sel Osteosit pada Penyembuhan Soket Pasca Pencabutan Gigi Tikus Wistar secara In Vivo

Abstract

Tooth extraction is the main cause of 90% of bone damage and has the potential for risk of infection or bleeding. After tooth extraction, an injury will result, called a socket. Tooth extraction sockets occur because the amount of bone exposed is quite large but the healing process is inadequate. The wound healing process consists of inflammation, proliferation, and remodeling phases. In wound healing, osteocytes play a role in bone remodeling by maintaining the integrity and vitality of new bone. Efforts to increase remodeling require supportive therapy containing Omega 3, EPA, and DHA. One natural supportive therapy ingredient that can be used is mackerel. Mackerel contains Omega-3, EPA, and DHA which is the main and typical commodity of all types of fish in the North Sumatra Sea. This study aims to test the effectiveness of administering mackerel fish oil on the number of osteocyte cells in socket healing after Wistar rat tooth extraction in vivo. This research is an in vivo experimental study using 24 Wistar rats as research samples on the 21st and 28th days of observation, then examined using the residual socket volume formula and histological examination. The results showed a significant effect based on the T-Independent and ANOVA test (p<0.05). The group given mackerel fish oil emulgel showed more osteocyte cells and accelerated wound closure compared to the 21st and 28th days and the negative control group without treatment.