Respons Antiinflamasi Nanogel Ekstrak Kulit Buah Delima (Punica Granatum L.) terhadap Jumlah Sel Limfosit pada Gingiva Tikus Wistar Jantan

Abstract

Inflammation is the immune system's response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or radiation, and acts by eliminating the injurious stimuli and initiating the healing process. Inflammation of the gingiva is called gingivitis. Lymphocyte cells are specific chronic inflammatory cells acting as a host immune response to an injury during chronic inflammation. Pomegranate peel contains several ingredients that play an anti-inflammatory role, such as ellagic acid and flavonoids. The purpose of this study is to determine the effect of giving pomegranate peel extract on the number of lymphocyte cells in the gingiva of wistar rats induced by ligature wire. This research was a laboratory experiment with a post test only control group design with a total sample of 30 male wistar rats divided into 5 groups (placebo, pomegranate peel extract nanogel 25%, 12,5%, 6,25%, and gengigel) and divided into two days of observation (3rd and 7th day). The research results based on the Kruskal-Wallis test showed significant differences between all groups. In this study it can be concluded that there is an anti-inflammatory effect of pomegranate peel extract nanogel in reducing the number of lymphocyte cells in the gingiva of male wistar rats induced by ligature wire with an effective concentration of 25%.