Kejadian Sepsis – Induced Acute Kidney Injury yang Diberikan Renal Replacement Therapy terhadap Mortalitas Pasien pada Perawatan ICU Telaah Sistematis

Abstract

Background. Sepsis causes organ dysfunction due to impaired body response to infection and is life threatening. Sepsis is one of the most common etiologies of acute kidney injury, especially in critically ill patients, which affects the prognosis and increases the risk of death of patients in the intensive care unit. Sepsis-induced acute kidney injury is related to the risk of death and high mortality, there is a high correlation in causing patient morbidity and mortality. Acute kidney injury due to sepsis causes mortality rate for more than 70%. Various studies have found that patients admitted to the intensive care unit show an increased mortality rate of 30%. Objective. To determine the relation between sepsis-induced acute kidney injury given Renal Replacement Therapy to the mortality rate of patients treated in intensive care unit. Method. This systematic review was conducted by collecting previous research journals from the year 2011 to 2021 according to the inclusion criteria determined in this study and keyword searches using the Advanced MeSH Terms from Cochrane, PubMed, Science Direct, and Google Scholar databases. Results. From 1.920 literatures, there are 4 studies that were included in this systematic review. The results show that this study supports the theory that early initiation of renal replacement therapy can reduce mortality in sepsis-induced acute kidney injury patients in intensive care unit. Conclusion. Sepsis-induced acute kidney injury patients who were given renal replacement therapy “early” showed lower mortality than those who were given renal replacement therapy “late”.