Korelasi antara Kadar Fibrinogen dengan Skor Snappe-II pada Sepsis Neonatorum sebagai Faktor Prediktif Mortalitas

Abstract

Objective: To determine the correlation between fibrinogen level with SNAPPE-II score in neonatal sepsis as a predictive factor of mortality. Method: A prospective cohort study was conducted on neonatal with sepsis in Perinatology Unit Haji Adam Malik General Hospital, Medan. Assessment of SNAPPE-II score, serum fibrinogen level performed within 12 hour after admission. Pearson’s correlations test were used to examine the association between fibrinogen level and SNAPPE-II score. Differences in the fibrinogen level and mortality were tested with independent T-test. Result: 35 subjects were recruited in this study. Fibrinogen level was negatively correlated with SNAPPE-II score (r=-0.435, p=0.009) and had a significant association with the mortality rate (p<0.021). Fibrinogen level could be used as a predictive factor of mortality (AUC 71.7%, p=0.028) with a cut-off point of 157.5mg/dL (66.7% sensitivity, 82.4% specificity, RR 2.6) Conclusion: Serum fibrinogen levels have negative correlation with SNAPPE-II score as a predictive factor of mortality in neonatal sepsis.