Hubungan antara Derajat Fungsi Motorik Kasar Berdasarkan Gross Motor Function Classification System (GMFCS) dengan Status Vitamin D pada Anak Palsi Serebral di RSUP H. Adam Malik Medan

Abstract

Background : Cerebral palsy (CP) is a motor and postural disorder due to impaired brain development. CP are vulnerable to developing vitamin D deficiency, due to poor sunlight exposure, inadequate vitamin D intake, and long-term use of anti-epileptic drugs that interfere with vitamin D metabolism that can result in reduced bone mineral density, osteopenia, and rickets. Objective: Determine the correlation between gross motor function based on Gross Motor Function Classification System (GMFCS) levels with vitamin D status in children with cerebral palsy at H. Adam Malik General Hospital, Medan. Methods: : A Cross-sectional study was done from November 2022 to April 2023 in the neurology pediatric outpatient clinic of H. Adam Malik General Hospital Medan. Children with cerebral palsy aged 2 to 6 years underwent the GMFCS levels and measuring 25(OH)D level. GMFCS levels was classified into 2 groups, ambulatory (GMFCS I, II, III) and non-ambulatory (GMFCS IV-V). Vitamin D status was defined on serum 25(OH)D levels as normal (30–100 ng/mL), insufficiency (21–29 ng/mL), deficiency (<20 ng/L). Results: Eighty five children with CP were included in this study, most of them were spastic type (75.3%), mainly spastik quadriplec and diplegic CP, and were in GMFCS non ambulatory (67%). Etiology of PS mainly occurs in the perinatal period (66.7%). Malnutrition was found in 75.3% subject. The prevalence of vitamin D deficiency in children with CP is 54.1%. There was a significant correlation between GMFCS levels with vitamin D status (OR 6,13, p < 0,003) Conclusion: GMFCS levels was significant correlation with vitamin D status in children with cerebral palsy