Evaluasi Waktu Pertumbuhan Epitel Pada Rawatan Luka Bakar Dermis pada Tikus Wistar dengan Penggunaan Madu Liar Dibandingkan dengan Madu Peternakan

Abstract

Background: Globally, burns are one of the most common types of injuries. After emergency management is done, other attention that must be focused is scarring and healing of the burn itself. The use of honey in burns has been shown in various literature to reduce inflammatory reactions, accelerate wound healing, and better infection control, with less chance of causing contractures or hypertrophic scarring Method: Experimental research using experimental animals (mice) and using a post-test control group design. The laboratory rats used were male Winstar strain Rattus norwegicus species, aged 9-12 weeks, body weight 150-200 grams, types of food and drink, and the treatment was all conditioned the same. Results: Day 1 burn area had an average of 194.16 ± 1.72 mm2 in the control group, 191.67 ± 3.72 mm2 in the Nusantara honey group, 194.83 ± 2.63 mm2 in the hanuka honey group, 188.5 ± 1.37 mm2 in the wild honey group and 193.5 ± 3.01 mm2 in the silver sulfa group. To compare the results of the examination with the ANOVA test followed by the Bonferonni post-hoc test. The burn area of day 21 had an average of 129.5 ± 13.57 mm2 in the control group, 101.5 ± 9.5 mm2 in the Nusantara honey group, 95.67 ± 24.99 mm2 in the hanuka honey group, 79.66 ± 11.77 mm2 in the wild honey group and 114.67 ± 7.71 mm2 in the silver sulfa group. The results of statistical analysis showed that the honey group had clinical significance compared to the control group but the type of honey did not affect the healing of burns. When compared to the administration of silver sulfa which was no different from the control, it appeared that wild honey had a better effect. Conclusion: The results showed that all three types of honey had clear efficacy against healing mid-dermal burns judging from the surface area of the wound.