Ekspresi Imunohistokimia L1CAM Berdasarkan Subtipe dan Grading Histopatologi Karsinoma Endometrium di Rumah Sakit Haji Adam Malik Medan dan Rumah Sakit Prof. Dr. Chairuddin P. Lubis Universitas Sumatera Utara Tahun 2018-2022

Abstract

Background: Endometrial cancer is a malignant neoplasm of epithelial cells that shows varying proportions of glands with papillary and solid architecture with endometrioid cell differentiation (resembling the endometrium). Histopathological classification based on tumor morphology and tumor grade has played an important role in the management of endometrial carcinoma, allowing prognostic stratification into different risk categories, and guiding surgical and adjuvant therapy. There are several additional prognostic factors that may further refine the prognostic stratification of endometrial carcinoma. Additional prognostic markers by examining immunohistochemical factors, such as expression of the transmembrane L1 cell adhesion molecule (L1CAM). L1CAM has emerged as one of the most promising. Objective: To determine the immunohistochemical expression of L1CAM in subtypes and histopathological grading of endometrial carcinoma. Materials and methods: This research is a descriptive study with a cross sectional approach on 23 hysterectomy samples diagnosed with endometrial carcinoma by staining with hematoxylin and eosin (H&E) and L1CAM immunohistochemistry. Results: Of the 23 samples, L1CAM immunohistochemistry based on the endometrial carcinoma subtype was most commonly found in the endometrioid carcinoma NOS subtype which expressed positively in 7 cases (46.7%) and based on endometrial carcinoma grading it was high grade endometrial carcinoma in 15 cases (88.2%). %). Conclusion: L1CAM immunohistochemical examination based on positive expression in high grade endometrial carcinoma.