Hubungan Kadar Eosinofil Darah dengan Tingkat Eksaserbasi, dan Hospitalisasi pada Penderita Asma di Poliklinik Paru RS USU

Abstract

Background: Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. According to the World Health Organization (WHO) and the Global Initiative for Asthma (GINA), there are 300 million people with asthma in the world, and this number is expected to grow to 400 million by 2025. In patients with asthma on medication, the severity of asthma is assessed based on the clinical features of asthma and the treatment regimen. According to the Global Initiative for Asthma (GINA), asthma management guidelines aim to achieve controlled asthma. However, in reality, the guidelines are not implemented effectively in daily practice so that there are still many uncontrolled asthma conditions. Inflammation that occurs in asthma is a typical inflammation that is accompanied by eosinophil infiltration, this is what distinguishes asthma from other airway inflammatory disorders. Objective To determine the relationship between blood eosinophil levels with the level of exacerbation and hospitalization in asthma patients at the USU Hospital Pulmonary Polyclinic. Methods: This study is a type of analytic observational research with a retrospective cohort approach, without intervening in research subjects. The research will try to look backward (backward looking), see the cause of the effects that have been found. Total sample 25 patients Results: Based on the results of the study, it can be seen that the age of asthma patients is mostly in the age category 26-50 years as many as 11 patients (44%). Based on the results of the study, it can be seen that patients with eusinophil levels <100 are the most patients, namely 21 people (84%). Based on the results of the study, it is known that asthma patients with severe exacerbation levels were 18 people (72%). Based on the results of the study, it is known that asthma patients with uncontrolled asthma tightness are 10 people (40%). Based on the results of the study it is known that asthma patients who did not receive hospitalization were 18 people (72%). Based on the results of the study obtained a P value of 0.976, because the P value is greater than 0.05, there is no relationship between eosinophil levels and the exacerbation rate of asthma patients.