Hubungan antara Kadar Angiotensin Converting Enzyme (ACE) dengan Selulit

Abstract

Background: Cellulite is a local metabolic disorder in subcutaneous tissue characterized by changes in skin topography, occurring in parts of the body with a large accumulation of fat tissue, especially thighs, buttocks, hips, and abdomen. Angiotensin converting enzyme is a zinc metallopeptidase, distributed on the surface of endothelial cells. Increased ACE levels cause microcirculation disorders, adipocyte hypertrophy, increased extracellular matrix, and stimulate the emergence of inflammatory cytokines which will cause an increase in the inflammatory response in the tissue, stimulate fibrogenic response and influences the appearance of cellulite. Objective: To determine the relationship between ACE levels and cellulite. Subjects and Methods: This research was an observational analytical study with a cross-sectional design, involving 40 cellulite patients and 40 control who meet inclusion and exclusion criteria. Each patient underwent anamnesis and dermatological examination. Then take blood samples to assess ACE levels using the ELISA test. These data were analyzed statistically using the Chi square test. Results: In this study, it was found that the highest age group who experienced cellulite was 42,5% aged 26–35 years. Most of them have a family history of cellulite, 55% of mothers. The majority of locations where cellulite occurs are in the femoral and gluteus regions, 67,5%. The mean ACE level in cellulite was 66,7815,38 μg/ml. The results showed that there was a relationship between high ACE levels causing 4,5 times risk of cellulite (p=0.002). Conclusion: There is a relationship between high ACE levels causing cellulite.