Hubungan antara Kadar Fibronektin Plasma dengan Stretch Marks

Abstract

Background: Stretch marks or striae distensae are linear atrophic scars that form in areas of skin damage as a result of skin stretching. Mast cell degranulation and activation of macrophages occur as well as changes in the components of the extracellular matrix, including fibronectin. Fibronectin as a dimeric glycoprotein and components contained in the extracellular matrix, functions as a regulator of cellular processes, to maintain tissue and functions in the process of wound healing in tissues Objective: To determine the relationship between plasma fibronectin levels and stretch marks. Subjects and Methods: This study was an observational study with a crosssectional design involving 40 females with stretch marks and 40 females without stretch marks who fulfilled inclusion and exclusion criteria in this study. Each research subject underwent anamnesis, physical examination, dermatological examination, and blood sampling to assess plasma fibronectin levels using the ELISA test. These data were analyzed statistically using the Chi square test. Results: In this study, it was found that the highest age for stretch marks was 18– 25 years, 33 people (82.5%). Most of them had a family history of stretch marks, 20 people (50%). The location where stretch marks occur mostly occurs in region gluteus 10 people (25%). The average fibronectin level in stretch marks was 259.541 ng/mL. The results of this study showed that there was a relationship between plasma fibronectin levels which caused a high risk of 2.85 times for stretch marks Conclusion: There was a relationship between plasma fibronectin levels and stretch marks.