Formulasi dan Karakterisasi Sediaan Body Scrub Karboksimetil Kitosan sebagai Antibakteri

Abstract

Chitosan has a well-developed function in a variety of fields and products. One of the interesting functional properties of the chitosan to develop is its properties as antibacterial that can remove dead skin cells and also as an antioxidant. Skin damage can be reduced by using body scrub because it can remove dead skin cells and lock moisture on the skin. The study aims to formulate a body scrub where the concentrations of carboxymethyl chitosan added vary between 0.5%, 1% and 1.5%, which can inhibit the activity of gram-positive bacteria Staphylococcus epidermidis. The determination of optimal stability and formula was obtained from the body scrub evaluation which included pH tests, viscosity tests, emulsion stability tests and hedonic tests, volunteer irritation tests, and antibacterial tests. The results of the 8 week study showed that the body scrub meets the pH test requirements (4,5-8) of SNI 16-4339-1996, the viscosity test (2,000-50,000 cP) is improved and qualifies SNI16-4399-1996. For the test of the highest antibacterial activity at a concentration of 1,5% chitosan for bacteria Staphylococcus epidermidis with a barrier zone diameter of 10,12 mm.