Perbedaan Kadar Interleukin 6 (IL-6) pada Saliva Antara Perokok dengan Non Perokok dan Hubungannya dengan Ph dan Laju Alir Saliva

Abstract

Smoking can cause changes in interleukin 6, salivary flow rate, and salivary pH. The aim of this study was to determine the differences in interleukin 6 levels between smokers and non-smokers and also the relationship between interleukin 6 with salivary flow rate and salivary pH. The type of this research is descriptive analytic with a cross-sectional design. The subjects of this research were 30 people who were divided into 15 smokers and 15 non-smokers and the saliva of these subjects was measured. The results of this study showed that the mean value of interleukin 6 levels in smokers was 4.36 ± 0.89 and 1.49 ± 0.51 in non-smokers. The Mann-Whitney test shows a p value of 0.000 (p<0.05) for interleukin 6 between smokers and non-smokers. Spearman’s rho test shows a r value of -0,653 and p value of 0,000 between interleukin 6 and salivary flow rate on smokers and non-smokers and shows a r value of -0,634 and p value of 0,000 between interleukin 6 and salivary pH on smokers and nonsmokers. It can be concluded that interleukin 6 levels in smokers are higher than in non-smokers and there is a significant correlation between interleukin 6 with salivary flow rate and salivary pH.