Korelasi Ekspresi Imunohistokimia Light Chain 3B dengan Grading Histopatologi pada Adenokarsinoma Kolorektal

Abstract

Background: Colorectal cancer ranks third highest of all malignancies in men and women worldwide. In Indonesia, colorectal cancer ranks fourth out of the 10 most common cancers encountered. Histopathologically, more than 90% of colorectal cancers are of the adenocarcinoma type. Several recent studies have been aimed at the mechanism of autophagy, having a dual role in tumorigenesis, namely as a tumor suppressor (in the early stages) and as a tumor promoter. Microtubule-associated protein 1 light chain 3B (LC3B) is one of the widely used autophagy markers. The role of autophagy as a cytoprotective in cancer cells and as an inhibitor of tumors also requires further research so that LC3B as one of the autophagy markers can be considered as one of the predictors of prognosis, especially in colorectal adenocarcinoma. Objective: Determine the correlation of Light Chain 3B immunohistochemical expression with histopathological grading in colorectal adenocarcinoma. Materials and Methods: This study is an analytic study with a cross-sectional approach that aims to assess the immunohistochemical expression of Light Chain 3B and its correlation with colorectal adenocarcinoma grading. Results: There was a significant relationship between LC3B immunohistochemical expression and histopathological grading of colorectal adenocarcinoma. Immunohistochemical expression of LC3B has a very strong correlation with the histopathological grading of colorectal adenocarcinoma and in a positive direction where the higher the grading of colorectal adenocarcinoma, the higher the immunohistochemical expression of LC3B, and vice versa.