Hubungan Kadar IL-6 dan Kualitas Tidur terhadap Sindrom Depresif pada Pasien Kanker Payudara Stadium Lanjut di RSUP H Adam Malik Medan

Abstract

Background: Cancer is one of the most important challenges in health systems worldwide today. Data by GLOBOCAN in 2020 there were 2.3 million new cases, representing 11.7% of all cancer cases. The prevalence of breast cancer in Indonesia reached 42.1 people per 100 thousand. The prevalence of depressive disorders in breast cancer patients worldwide is 32.2%. Pro-inflammatory cytokines, which are signalling molecules that trigger inflammatory responses in the body, play an important role in the pathogenesis of breast cancer. Stress is associated with significantly increased levels of cytokines, including interleukin-6 (IL-6), which is also associated with increased negative mood and anxiety. Women with breast cancer experienced significantly worse fatigue, more disrupted circadian activity rhythms, poorer sleep quality, and more depressive symptoms at the end of the chemotherapy cycle compared to baseline levels and free controls. Method: This research is a correlative analytic study with a cross-sectional study approach. Sampling using non probability sampling technique type consecutive sampling. A sample of 54 patients with advanced breast cancer at the Hospital. H. Adam Malik Medan. IL-6 levels were measured using the ELISA method, while sleep quality and depressive syndrome data were measured using a questionnaire. Statistical analysis was performed using Pearson correlation test and linear regression. Results: Data from 54 participating advanced breast cancer patients showed that there was a strong positive correlation between IL-6 levels and advanced breast cancer where the higher the IL-6 level, the higher the stage of breast cancer, r = 0621, n = 54 and p value <0.001, there is a strong positive correlation between IL-6 levels and depressive syndrome in advanced breast cancer patients where the higher the IL-6 level, the higher the level of depressive syndrome, r = 0.698, n = 54 and p value <0.001, there is a moderate positive correlation between sleep quality and depressive syndrome in advanced breast cancer patients where the worse the sleep quality, the higher the depressive syndrome (r = 0. 594, n = 54 and p value <0.001. Conclusion: This study showed an association between IL-6 levels and sleep quality with depressive syndrome in advanced breast cancer patients.