Korelasi Kadar Hepcidin terhadap Parameter Hematologi pada Ibu Hamil dengan Anemia Defisiensi Besi

Abstract

Background: Anemia is a common nutritional disorder among pregnant women worldwide, with increasing prevalence in Indonesia. This study investigates the correlation between hepcidin levels and hematological parameters in pregnant women with iron deficiency anemia (IDA). Hepcidin is a peptide hormone from the liver that plays a crucial role in iron homeostasis, with levels varying in different types of anemia. Objective: To determine the correlation between hepcidin levels and hematological parameters in pregnant women with iron deficiency anemia. Methods: A cross-sectional design involving 39 pregnant women with IDA. Hematological data and hepcidin levels were analyzed to determine correlations. Results: A significant inverse correlation was found between hepcidin levels and key hematological parameters. The average hemoglobin level was 10.18 ± 0.6 g/dL, hematocrit 31.75 ± 1.86%, MCV 77.2 ± 2.90 fL, MCH 27.43 ± 2.37 pg, and MCHC 29.03 ± 1.40 g/L. Hepcidin levels showed a very strong positive correlation with ferritin levels (r = 0.997, p < 0.001), indicating hepcidin as a reliable marker for diagnosing IDA in pregnant women. Conclusion: Hepcidin levels are inversely correlated with key hematological parameters in pregnant women with IDA. This finding highlights the potential of hepcidin as a diagnostic marker for IDA, which could improve early diagnosis and management, thereby reducing the risk of adverse maternal and fetal outcomes.