Pengaruh Karakteristik Demografi, Manifestasi Klinis, Parameter Laboratorium, dan Gambaran Radiologis terhadap Prognosis Jangka Pendek pada Penderita Meningitis Tuberkulosis

Abstract

Introduction Tuberculosis is the most common infectious disease in the world. This infectious disease is chronic and is caused by Mycobacterium tuberculosis in humans. Tuberculous meningitis is inflammation of the lining of the brain due to complications of primary tuberculosis infection. Therefore, the mortality rate in tuberculous meningitis patients is still high. Aim This study aims to determine the influence of demographic characteristics, clinical manifestations, laboratory parameters, and radiological features on the short-term prognosis of patients with tuberculous meningitis.. Method This study uses a prospective cohort design. Sampling was carried out in the Inpatient Room of H. Adam Malik General Hospital Medan. The research sample was taken as many as 31 subjects in total sampling. Data analysis used the Chi Square test and Logistic Regression Test. Result The majority of research subjects were women (51.6%), aged less than 40 years (61.3%), high school education level (54.8%), and private employees (41.9%). Based on the bivariate analysis test, there was no relationship between demographic characteristics (age, sex), clinical manifestations, laboratory and mortality. Based on medical conditions, clinical stage had an effect on outcome (p = 0.002). Based on the radiological picture, hydrocephalus was associated with mortality statistically (p = 0.003). Based on the multivariate analysis test, it was found that there was an advanced stage and the presence of hydrocephalus had an effect on mortality (p < 0.05).. Conclussion Advanced stages of tuberculous meningitis and hydrocephalus are independent prognostic factors for mortality.