Formulasi Nanosuspensi Parasetamol dengan Metode Top Down dan Uji Efek Antipiretik Analgetik

Abstract

Background: Paracetamol is hardly soluble in water, so the preparation of the solution often uses cosolven alcohol or propylene glycol. However, the use of alcohol is not safe for children, and propylen glycol has not long ago been forged with dietylene glycol and ethanyl glycol which causes acute kidney failure in children. Suspension is the solution to the problem, although suspensions have the shortcomings of caking. Therefore, the author is interested in making nanosuspension preparations, which do not contain cosolven and mixed solvents, and to prevent caking. Objective: To make paracetamol nanosuspension using the top down method, characterize, and test the effects of analgesic and antipyretic activity in vivo by comparing the preparation of suspension and solution. Methods: The research phase includes the identification of raw materials, the manufacture of paracetamol nanosuspension with the top down method, the characterization of nanosuppression includes organoleptic examination, particle size, zeta potential, pH, type weight, ratio, dissolution and stability test for 3 months. Then the testing of therapeutic activity using white mice included analgesic testing with the hot plate method with 5 treatment groups and antipyretic testing using 2-6-dinitrophenol induction with 6 treatment groups. Results: The values of paracetamol levels in nanosuspendants, suspensions and suitable parasetamol solutions are 108.22%, 94.45% and 103.26%. In analgesic and antipyretic tests showed nanosuspendants have better effects than suspensions, whereas with solutions have no significant differences. Conclusion: Based on research, it is concluded that paracetamol can be formulated in the form of nanosuspension using the top down method. Nanosuspendants dissolve faster than suspensions.