| dc.description.abstract | Background: Paracetamol is hardly soluble in water, so the preparation of the
solution often uses cosolven alcohol or propylene glycol. However, the use of
alcohol is not safe for children, and propylen glycol has not long ago been forged
with dietylene glycol and ethanyl glycol which causes acute kidney failure in
children. Suspension is the solution to the problem, although suspensions have the
shortcomings of caking. Therefore, the author is interested in making
nanosuspension preparations, which do not contain cosolven and mixed solvents,
and to prevent caking.
Objective: To make paracetamol nanosuspension using the top down method,
characterize, and test the effects of analgesic and antipyretic activity in vivo by
comparing the preparation of suspension and solution.
Methods: The research phase includes the identification of raw materials, the
manufacture of paracetamol nanosuspension with the top down method, the
characterization of nanosuppression includes organoleptic examination, particle
size, zeta potential, pH, type weight, ratio, dissolution and stability test for 3
months. Then the testing of therapeutic activity using white mice included analgesic
testing with the hot plate method with 5 treatment groups and antipyretic testing
using 2-6-dinitrophenol induction with 6 treatment groups.
Results: The values of paracetamol levels in nanosuspendants, suspensions and
suitable parasetamol solutions are 108.22%, 94.45% and 103.26%. In analgesic and
antipyretic tests showed nanosuspendants have better effects than suspensions,
whereas with solutions have no significant differences.
Conclusion: Based on research, it is concluded that paracetamol can be formulated
in the form of nanosuspension using the top down method. Nanosuspendants
dissolve faster than suspensions. | en_US |
