| dc.description.abstract | Films are thin sheets used to close and protect wounds. Films are often made
from materials such as starch and chitosan as an antibacterial agent for Pseudomonas
aeruginosa. Film making in the form of plaster is by mixing cassava starch with
variations of 5; 6; 7 and 8 grams and distilled water with variations of 78; 77; 76 and
75 mL, chitosan with a fixed composition of 2%, added with 2 mL of glycerol, stirred
until homogeneous, printed on an acrylic plate, dried in the oven for ± 2 days. The
best results were obtained 8 grams of cassava starch, 75 mL of distilled water, 50 mL
of 2% chitosan, and 2 mL of glycerol. From the research results on this variation gives
the best results with characteristic values such as thickness, tensile strength, and SEM
which are 1.21 MPa, 0.3 mm, has a surface structure that is increasingly organized
and compatible. The best film variation was tested for antibacterial against
Pseudomonas aeruginosa by disc diffusion method. The film with a variation of 8
grams of cassava starch produced an inhibition zone of 13,6 mm which was
categorized as a strong inhibition zone. The film in the form of plaster with the best
inhibition zone was tested preclinically on male white rats. Observation of the incision
wound given to white rats, can be healed within 6 days. | en_US |
