| dc.description.abstract | Background: Balakka (Phyllanthus emblica L.) is a plant from the
Phyllanthaceae family. This plant has a cardioprotective effect through the
mechanisms of reducing oxidative stress, reducing lipid peroxidation, increasing
endogenous antioxidant levels, and protecting against ischemia reperfusion injury.
Objective: To determine the effect of ethanol extract of balakka fruit on IL-17
and TNF-α of rats induced by L-NAME.
Methods: IL-17 and TNF-α biomarkers were measured in rats before and after
administration of ethanol extract of balakka fruit using the ELISA method. Mice
were divided into 6 test groups with each treatment, respectively, normal group,
positive control, negative control, and 3 extract test groups. The 5 groups that
were treated were induced by L-NAME for 30 consecutive days. On day 31, the
positive control group was given 12,5 mg/KgBW of captopril, while the extract
test group was given ethanol extract of balakka fruit at dose of 100, 300, and 500
mg/KgBW. Blood serum was taken and IL-17 and TNF-α levels were measured
using the appropriate ELISA kit.
Results: IL-17 and TNF-α levels in the normal group, positive control and EEBB
100, 300, and 500 mg/KgBW test groups were significantly different from the
negative control group. The EEBB 500 mg/KgBW test group was not significantly
different from the normal group and positive control.
Conclusion: EEBB can reduce the levels of IL-17 and TNF-α in rats induced by
L-NAME. | en_US |
