| dc.description.abstract | Background: Mulberry leaves (Morus alba L.) contain antioxidant compounds
such as alkaloids, flavonoids, polyphenols, and terpenoids that can prevent the
negative effects of free radicals. Free radicals can cause dry skin, necessitating the
use of moisturizing cosmetics in an appropriate form. Nanogel is a preparation
with nano-sized particles that can enhance the penetration and absorption of active
compounds.
Objective: To formulate and evaluate the effectiveness of nanogel preparation of
mulberry leaf extract as a facial moisturizer.
Method: Mulberry leaf simplicia was prepared through a drying process, followed
by characteristic testing and simplicia screening. The extraction of mulberry
leaves was carried out using the maceration method with 96% ethanol, followed
by characteristic testing and extract screening. The nanogel formulation used
Carbopol 940 as the gel base with variations in mulberry leaf extract
concentration 0% (F0), 1% (F1), 2% (F2), and 3% (F3). Evaluation of the nanogel
preparations included organoleptic, homogeneity, pH, viscosity, centrifugation,
spreadability, and particle size measurement, stability testing during storage at
room temperature for 12 weeks, cycling test, and moisture content skin testing.
Result: The characteristics of mulberry leaf simplicia were as follows moisture
content, water-soluble extract, ethanol-soluble extract, total ash, and acidinsoluble
ash were 8.65; 26.37; 14.28; 9.20 and 4.03% respectively. The
characteristics of mulberry leaf extract were as follows: moisture content, total
ash, and acid-insoluble ash were 6.62; 4.03; and 0.79% respectively. Both
simplicia and extract of mulberry leaves contained secondary metabolites such as
alkaloids, flavonoids, tannins, saponins, glycosides, and steroids/triterpenoids.
The resulting nanogel preparation was dark green, had a distinctive extract odour,
semi-solid, was homogeneous, had a pH of 5.68-5.91, viscosity of
5999.93 16373.13 cP, showed no phase separation after centrifugation, had
spreadability of 5.03-6.70 cm, was stable for 12 weeks at room temperature and
after the cycling test, and had particle sizes ranging from 53-311 nm. The
percentage of total increase in skin moisture content for F0, F1, F2, and F3 was
10.98; 33.44; 68.61; dan 115.42% respectively.
Conclusion: The mulberry leaf ethanol extract (Morus alba L.) can be formulated
in a nanogel preparation that is stable at room temperature storage for 12 weeks
and meets the physical evaluation requirements. Mulberry leaf ethanol extract
nanogel preparation is effective in increasing facial skin moisture with sig. < 0.05
between F3 and F0 (blank) after four weeks of use. | en_US |
