Uji Efek Teratogenik Ekstrak VCO Kurkuminoid dari Rimpang Kunyit (Curcuma domestica Val.) terhadap Berat dan Panjang Fetus Tikus Putih Betina

Abstract

Background: Turmeric (Curcuma domestica Val.) contains curcuminoid compounds in the form of yellow phenolic pigments known to have immunomodulatory activity. These properties have the potential to be developed into a practical and safe herbal medicine that is widely used in the community, including pregnant women. Objective: The purpose of this study was to determine the teratogenic effect of giving curcuminoid VCO extract from turmeric rhizomes (Curcuma domestica Val.) on the weight and length of the fetus of the female white rats. Method: Curcuminoid VCO extract was obtained using Microwave Assisted Extraction (MAE) method with VCO solvent. Then the identification of curcuminoids from curcuminoid VCO extract with KLT. The teratogenic effect test was conducted by giving the test preparation to pregnant rats that had been divided into 5 groups, namely the normal control group, positive control (Gabapentin 48 mg/kg bw), curcuminoid VCO extract at doses of 400, 800 and 1000 mg/kg bw during organogenesis. Observations of the toxic effects of pregnant rats include body weight and mortality. Observations of teratogenic effects include resorption, hemorrhage and death, number, body weight and body length of fetuses. Result: Based on the results of the study, the number of fetuses showed no significant difference (p>0.05) between the curcuminoid VCO extract group doses of 400, 800 and 1000 mg/kg bw with the normal group. In the observation of the extract group, there was a significant difference (p<0.05) on the decrease in body weight and length of the fetus, increase in the number of dead fetuses and resorption compared to the normal control group. Resorption was observed after treatment with 1000 mg/kg bw dose of extract. Conclusion: It can be concluded that curcuminoid VCO extract exerts a teratogenic effect on the weight and length of the fetus of the female white rats given during the period of organogenesis.