| dc.description.abstract | Background: Turmeric (Curcuma domestica Val.) contains curcuminoid
compounds in the form of yellow phenolic pigments known to have
immunomodulatory activity. These properties have the potential to be developed
into a practical and safe herbal medicine that is widely used in the community,
including pregnant women.
Objective: The purpose of this study was to determine the teratogenic effect of
giving curcuminoid VCO extract from turmeric rhizomes (Curcuma domestica
Val.) on the weight and length of the fetus of the female white rats.
Method: Curcuminoid VCO extract was obtained using Microwave Assisted
Extraction (MAE) method with VCO solvent. Then the identification of
curcuminoids from curcuminoid VCO extract with KLT. The teratogenic effect test
was conducted by giving the test preparation to pregnant rats that had been divided
into 5 groups, namely the normal control group, positive control (Gabapentin 48
mg/kg bw), curcuminoid VCO extract at doses of 400, 800 and 1000 mg/kg bw
during organogenesis. Observations of the toxic effects of pregnant rats include
body weight and mortality. Observations of teratogenic effects include resorption,
hemorrhage and death, number, body weight and body length of fetuses.
Result: Based on the results of the study, the number of fetuses showed no
significant difference (p>0.05) between the curcuminoid VCO extract group doses
of 400, 800 and 1000 mg/kg bw with the normal group. In the observation of the
extract group, there was a significant difference (p<0.05) on the decrease in body
weight and length of the fetus, increase in the number of dead fetuses and resorption
compared to the normal control group. Resorption was observed after treatment
with 1000 mg/kg bw dose of extract.
Conclusion: It can be concluded that curcuminoid VCO extract exerts a teratogenic
effect on the weight and length of the fetus of the female white rats given during
the period of organogenesis. | en_US |
