Korelasi Kadar Kortisol dan Estradiol dengan Depresi, Kecemasan dan Gejala Terkait Menopause pada Wanita Pascamenopause

Abstract

Background. Menopause is defined as the permanent cessation of menstrual cycles due to loss of ovarian follicular function. It is often accompanied by significant physical and mental changes, including vasomotor symptoms, osteoporosis, cardiovascular disease, and cognitive and psychological problems such as depression and anxiety. It is estimated that by 2030, 1.2 billion women will be in the menopause or postmenopausal period. Methodology. This study is an analytic study with a cross sectional design to assess the relationship of salivary cortisol and estradiol levels with depression, anxiety, and menopause-related symptoms in Postmenopausal women. This study was conducted at Department of Obstetric And Gynecology Faculty of Medicine Universitas Sumatera Utara from August 2024 until the sample size was met. Results. There was a positive correlation between cortisol levels with depression and anxiety and menopause-related symptoms (p=0.30; p=0.038). Increased cortisol levels increase the level of depression, anxiety and menopause-related symptoms. Estradiol levels have a negative / opposite correlation, which means that increasing estradiol levels can reduce the level of depression, anxiety and symptoms related to menopause (p = 0.20, p = 0.042). Conclusion. Cortisol and estradiol levels affect the level of depression, anxiety and symptoms related to menopause.