Perbandingan Aktivitas Anti Inflamasi Ekstrak Etanol Bawang Putih Tunggal (Allium sativum L.var.solo garlic) dengan Bawang Hitam Tunggal terhadap Tikus yang Diinduksi Karagenan

Abstract

Background : Solo black garlic is one of the processed products of solo garlic. Garlic and black garlic contain organosulfur compounds and have various properties, one of which is anti-inflammatory. Several studies have proven the anti-inflammatory activity of solo garlic but there is no information regarding the comparison of anti-inflammatory activity between solo garlic and solo black garlic. The content of alicin and flavonoid compounds has anti-inflammatory properties. Objective: To determine the comparison of anti-inflammatory activity of ethanol extract of solo garlic and solo black garlic and see the effective dose as an anti-inflammatory. Method: : Anti-inflammatory testing of ethanol extracts of solo garlic and solo black garlic using the method of swelling of the soles of rats induced by λ-carrageenan using a digital pletismometer for 6 hours with the principle of measurement based on Archimedes' law. The study was divided into 6 treatment groups consisting of 5 rats in each treatment. Negative control group (Na-CMC suspension 0.5%), positive control (Na-Diclofenac dose 2.25 mg/kg BB), test group I Solo Garlic Ethanol Extract (EEBPT) 100 mg/kg BB, test group II Solo Garlic Ethanol Extract (EEBPT) 300 mg/kg BB, test group III (EEBHT) 100 mg/kg BB and group IV (EEBHT) 300 mg/kg BB. Based on the research data, the percentage of inflammation and the percentage of inflammation inhibition were calculated. Data were analysed with ANOVA and Kruskal-wallis tests to see differences between groups. Results : : EEBPT doses of 100 mg/kg BB, 300 mg/kg BB and EEBHT doses of 100 mg/kg BB, 300 mg/kg BB have an effect as anti-inflammatory. EEBHT 300 mg/kg BB is an effective dose as an anti-inflammatory, where the highest percent value of inflammation inhibition is at the 6th hour of 91.07 ± 1.88 and is not significantly different from the positive control Na-Diclofenac (p>0.05). Conclusion : EEBPT and EEBHT doses of 100 and 300 mg/kg BB have anti-inflammatory activity. EEBHT showed more effective anti-inflammatory activity than EEBPT at a dose of 300 mg/kg BB.