| dc.description.abstract | Background: Metfomin Hydrochloride when administered orally about 40% of the
dose is absorbed in the upper small intestine (duodenum and jejenum) and only 10%
is absorbed in the ileum therefore it has a low bioavailability of 50-60%,
administration of metformin by immediate release the most common side effects
are nausea and vomiting and discomfort in the stomach, Gastroretentive Drug
Delivery System is a system approach designed to extend the residence time of
drugs in the stomach to increase drug bioavailability.
Objective: Making a gastroretentive preparation of metformin HCl from nata de
coco matrix and Na CMC polymer that can be retained in the stomach and is able
to provide sustained release.
Method: Metformin HCl gastroretentive printed beads were prepared using nata de
coco pulp, mucilago Na CMC 10% in distilled water and lactose in different ratios.
The mixture of nata de coco pulp, mucilago Na CMC, and lactose containing
metformin HCl was printed using a 1,2 cm diameter beverage pipette and dried at
room temperature for 5×24 hours. The floating, swelling, integrity, and release
properties of the printed beads were tested using the USP dissolution apparatus
paddle method in artificial stomach medium pH 1,2 for 12 hours. The mucoadhesive
properties were tested using 1×1 cm rat gastric mucosa with a DuNuoy tensiometer.
Results: The experimental results showed that F8a (1:2) F8b (1:1) and F8c (2:1)
printed beads provided good characteristics as a gastroretentive drug delivery
system with slow or gradual drug release. Floating properties before the occurrence
of gastric emptying time (2-3 hours) shown from Floating Lag Time 36±5,65
minutes, 8±5,40 minutes, 34±9,62 and Floating Duration Time 12 hours, printed
beads have unqualified swelling properties because the preparation is not larger
than the diameter of the pylorus at (2-3 hours), mucoadhesive properties show the
results of 67,26±0,15 dyne/cm2 where these results have better mucoadhesive
strength than other formulas. The printed beads are able to provide a slower and
gradual release or meet the requirements of sustained release marked in formulas
F8a and F8b at 12 hours 80,01% and 81,55% with a sustained release requirement
of 12>75%.
Conclusion: nata de coco-Na CMC printed beads have good gastroretentive
properties with the best release profiles being F8a, F8b and F8c, respectively. | en_US |
