| dc.description.abstract | Breadfruit (Artocarpus altilis) contains starch up to 8.93 %, and starch has a very
wide range of benefits in the industrial world. The physicochemical properties of
starch have obstacles when used directly including viscosity, swelling power, low
solubility, low retrogradation, limited digestibility, and poor thermal stability. Starch
modification is needed to improve the physicochemical properties of starch, among
others, by modifying starch in nanoparticle size and double modified. The method used
for modification of nanoparticle size through acid hydrolysis, crosslink modification
using CH3COONa crosslink agent 30% of starch weight and oxidized using H2O2 30%,
The average size of starch nanoparticles is 133 nm and has increased the average
particle size after double modified 917 nm. FTIR results experienced a change in
intensity that is not sharper at wave numbers 1640 cm-1 and 3257 cm-1, which indicates
that crosslinking and oxidation have occurred. The thermal properties of the
gelatinization temperature obtained increased significantly, namely the starting
temperature (T0) 110.31 ℃, peak temperature (Tp) 112.25 ℃, final temperature (Tc)
117.61 ℃, with gelatinization enthalpy energy (ΔHgel) 114.15 J/g. The surface
morphology showed a significant difference in the shape of starch granules, damaged
starch granules that had a rough and irregular surface. The result of the degree of
substitution is 0.0162, the carbonyl content of starch that has been oxidized reaches
0.9800%, and the carboxyl content is 0.1125%. The physicochemical properties of
double-modified starch nanoparticles have a solubility of 86.79%, a swelling power
of 1.480 g/g, and the lowest viscosity of 0.94 Cp. The results of drug loading analysis
showed that the double-modified starch nanoparticles have the ability to encapsulate
a high amount of drug as a delivery preparation compared to breadfruit starch,
breadfruit starch nanoparticles and, crosslinked breadfruit starch nanoparticles under
alkaline conditions in the intestine reached 1.52 mg/g and acidic conditions in the
stomach reached 0.87 mg/g. | en_US |
