Evaluasi Penggunaan Komposit Selulosa Asetat/Karbon Dots sebagai Bahan Pelepasan Obat

Abstract

Composite materials of cellulose acetate with Carbon Dots (CDs) offer significant potential as efficient drug delivery systems. This study evaluates cellulose acetate/CDs (CA/CDs) composites as drug release materials by synthesizing CDs from the leaves of the Moses-in-the-cradle plant (Rhoeo discolor) using a hydrothermal method. The synthesis aims to utilize the potential of plants rich in phenolic compounds as a precursor for CDs. In this study, the compatibility of CDs with blood and the release rate of CDs from the CA/CDs composite were tested. The synthesis method involves the preparation of Rhoeo discolor leaf into powder, followed by autoclaving and filtration to produce CDs. The CA/CDs composite was then prepared by mixing CDs with cellulose acetate and was characterized for its physical and chemical properties, including UV-Vis spectroscopy, HR-TEM, FTIR, hemolytic tests, and release tests in water. The results indicated that CDs could be successfully formed from Rhoeo discolor leaves as precursors, were compatible with blood, and demonstrated an increased release rate with prolonged immersion time. This study provides new insights for the development of CA/CDs-based drug delivery systems, potentially enhancing the effectiveness of drug therapy through more controlled delivery methods.